Skin / Melanoma Chemotherapy Regimens

The information contained in these regimens is a statement of consensus of NCCP and ISMO or IHS professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgment in the context of individual clinical circumstances to determine any patient's care or treatment.The treatment regimen to be used should take into account factors such as histology, molecular pathology, age, performance status, co-morbidities and the patient’s preference.  Each treatment regimen has advantages and disadvantages, and there may be more than one good option.  In addition, treatment choices can change over time as more evidence becomes available. Use of these documents is the responsibility of the prescribing clinician and is subject to HSE’s terms of use.

Please email any comments or feedback on these regimens to oncologydrugs@cancercontrol.ie

Evidence into practice - a rapid review. Systemic anticancer treatment of patients with metastatic melanoma.

Skin/Melanoma Chemotherapy Regimens

Regimen Name Indication

Dabrafenib Monotherapy

Regimen

00237a

Treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation

Ipilimumab monotherapy

Regimen

00105a

Treatment of adults with advanced (unresectable or metastatic) malignant melanoma.

Nivolumab Monotherapy

Regimen

00349a

As monotherapy for the treatment of advanced (unresectable or metastatic) melanoma in adults

Nivolumab Ipilimumab Combination Therapy

Regimen

00431a

Nivolumab in combination with ipilimumab is indicated for the treatment of advanced (unresectable or metastatic) melanoma in adults

Pembrolizumab monotherapy

Regimen

00347a

First line monotherapy for the treatment of advanced (unresectable or metastatic) melanoma in adults.

00347b

For the treatment of ipiplimumab-refractory patients with unresectable or advanced metastatic melanoma.

Vismodegib Monotherapy

Regimen

00236a

Treatment of adult patients with symptomatic metastatic basal cell carcinoma (MBCC)

00236b

Treatment of adult patients with local advanced basal cell carcinoma inappropriate for surgery or radiotherapy.

Vemurafenib Monotherapy

Regimen

00102a

Treatment of adult patients with BRAF V600 mutation-positive unresectable or metastatic melanoma