Lynch Syndrome

 Lynch Syndrome Testing Pathways

The Lynch Syndrome Advisory Group recommended universal testing for Lynch syndrome in patients with newly diagnosed colorectal cancer, endometrial cancer or endometrioid/clear cell ovarian cancer. The aim is to improve identification and management of patients with Lynch syndrome.

• Implementing a universal testing pathway for Lynch syndrome in colorectal, endometrial and endometrioid or clear cell ovarian cancer (pdf, size 787.8 MB, 34 pages)

• Lynch Champion Step-by-Step Guide for the Colorectal Tumour Conference (pdf, size 1 MB, 10 pages)

• Implementing Lynch syndrome Testing Pathways in Colorectal Cancer – Information to support pathologists (pdf, size 1 MB, 10 pages)
• Lynch syndrome testing pathway: Guidance for the colorectal cancer (CRC) tumour conference – Template Standard Operating Procedure (SOP) (pdf, size 2.5 MB, 12 pages)    Word version

• Lynch Champion Step-by-Step Guide for the Gynaecological (Endometrial Cancer, Endometrioid or Clear Cell Ovarian Cancer) Tumour Conference (pdf, size 949 KB, 10 pages)
• Implementing Lynch syndrome Testing Pathways in Endometrial Cancer, Endometrioid or Clear Cell Ovarian Cancer – information to support pathologists (pdf, size 1 MB, 10 pages)
• Lynch syndrome testing pathway: Guidance for the Gynaecological Cancer (Endometrial Cancer, Endometrioid or Clear Cell Ovarian Cancer) tumour conference – Template Standard Operating Procedure (SOP) (pdf, size 2.5 MB, 12 pages)NCCP-SOP-Gynae.rtf (size 10.8 MB) Word version

These testing pathways are designed to identify patients who may have Lynch Syndrome and should be offered referral to a specialist cancer genetic service or mainstreamed testing by your own service.  See Mainstreaming Cancer Genetic Testing for resources to support a mainstreamed model.