Clostridium difficile

Doses are oral and for adults unless otherwise stated. Visit the Health Products Regulatory Authority (HPRA) website for detailed drug information (summary of product characteristics and patient information leaflets). Dosing details, contraindications and drug interactions can also be found in the Irish Medicines Formulary (IMF) or other reference sources such as British National Formulary (BNF) / BNF for children (BNFC). See guidance on dosing in children for quick reference dosage/weight guide. Refer to drug interactions table for detailed drug interactions for all antimicrobials. Note extensive drug interactions for clarithromycin, fluoroquinolones, azole antifungals and rifampicin. Many antibiotics increase the risk of bleeding with anticoagulants.

Note additional warnings for clarithromycin and fluoroquinolones

Comments from Expert Advisory Committee

When to suspect C. difficile infection (CDI)?

Diarrhoea in the presence of the following risk factors:

  • Recent or multiple antibiotic use
  • Elderly
  • Co-morbidities
  • Immunosuppression
  • Recent gastrointestinal surgery,
  • Recent hospital stay or exposure to person with CDI

If you suspect CDI: Send faeces to the microbiology laboratory for C. difficile toxin testing

Treatment: Confirmed C. difficile infection

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Patient Information

We recommend patients use the website developed by HSE/ICGP/IPU partnership www.undertheweather.ie for tips on how to get better from common infections without using antibiotics, what you can do for yourself or a loved one and when to seek help.

Reviewed May 2019


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