Clostridioides difficile - Antibiotic Prescribing

Comments from Expert Advisory Committee

When to suspect C. difficile infection (CDI)?

Diarrhoea in the presence of the following risk factors:

  • Recent or multiple antibiotic use
  • Elderly
  • Co-morbidities
  • Immunosuppression
  • Recent gastrointestinal surgery,
  • Recent hospital stay or exposure to person with CDI

If you suspect CDI: Send faeces to the microbiology laboratory for C. difficile testing

Treatment: Confirmed C. difficile infection

cdiff 12032021

Patient Information

We recommend patients use the website developed by HSE/ICGP/IPU partnership www.undertheweather.ie for tips on how to get better from common infections without using antibiotics, what you can do for yourself or a loved one and when to seek help.

Safe Prescribing (visit the safe prescribing page)

  • Doses are oral and for adults unless otherwise stated
  • Renal impairment dosing table
  • Drug interactions table. Extensive drug interactions for clarithromycin, fluoroquinolones, azole antifungals and rifampicin. Many antibiotics increase the risk of bleeding with anticoagulants.
  • Visit the Health Products Regulatory Authority (HPRA) website for detailed drug information (summary of product characteristics and patient information leaflets). Dosing details, contraindications and drug interactions can also be found in the Irish Medicines Formulary (IMF) or other reference sources such as British National Formulary (BNF) / BNF for children (BNFC).

Reviewed March 2021


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