The following guidance applies to the treatment of patients with a clinical diagnosis of CDI and supportive microbiological evidence of CDI
General measures advised in the treatment of patients with CDI:
- Patients/ residents of a healthcare facility with potentially infectious diarrhoea (i.e. no clear alternative cause) should be isolated with Standard and Contact Precautions as soon as possible
- Stop unnecessary antimicrobial therapy (if possible)
- Ensure adequate nutrition and replacement of fluid and electrolytes
- Avoid anti-motility medications
- Review proton pump inhibitor use
If an antibiotic is still essential, consider changing to one with a lower risk of causing CDI. It is preferable to use agents with as narrow spectrum as possible. Almost all antibiotics increase the risk of CDI but clindamycin, cephalosporins, ciprofloxacin (and other fluoroquinolones) and co-amoxiclav are well-documented as having the greatest risk.