Mastitis - Antibiotic Prescribing

Comment from expert advisory group

  • Note higher and more frequent 6-hourly doses of antibiotics are required in mastitis treatment to ensure adequate tissue penetration.
  • Low dose i.e., 250mg or 8-hourly dosing may result in treatment failure.
  • Duration of treatment required can vary from 5 to 10 days.
  • Patients should be reassessed after 5 days as treatment failures do occur and referral to hospital may be necessary if not responding to treatment. If improving but not fully resolved, extend treatment course.
  • The patient should be encouraged to either breastfeed or express to ensure milk stasis does not occur. Cold compresses and analgesia should be used

Treatment

Drug Dose Duration +/- Notes
1st choice options   
Flucloxacillin 500mg-1g every 6 hours 5 to 10 days

Reassess after 5 days
of treatment as
failures do occur and
referral to hospital may
be necessary if not
responding to treatment.
If improving but not
fully recovered extend
treatment course.

2nd choice options / Penicillin Allergy    
Clindamycin 300mg-450mg every 6 hours 5 to 10 days

Patient Information

Safe Prescribing (visit the safe prescribing page)


Reviewed May 2022

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