This information on drug interactions with antimicrobials is intended for use as a guide and not as a complete reference source

Antibiotic Class Interacting Drug Comment

Cephalosporins e.g.

  • Cefaclor
  • Cefixime
  • Cefuroxime
  • Cefalexin
  • Cefazolin
  • Ceftriaxone
Zinc With cefalexin: risk of reduced bioavailability and efficacy. Separate the doses by 3 hours or more to avoid interaction.
Warfarin Penicillins and cephalosporins are preferred alternatives when patients are on warfarin. Documented reports of bleeding incidents with these antibiotics are rare even though a theoretical risk exists. Monitor INR during and after antimicrobial treatment and adjust warfarin dose as necessary.

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